Recombinant Human Kallikrein-11 (KLK11)

Uniprot Id

Q9UBX7

Target Species

Human

Target Name

KLK11

Target Full Name

Kallikrein-11

Target Function

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Target Subcellular Location

[Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.

Target Protein Families

Peptidase S1 family, Kallikrein subfamily

Target Tissue Specificity

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).

Target Synonyms

Hippostasin; hK11; Kallikrein 11; Kallikrein 11 isoform 1 preproprotein; Kallikrein 11 isoform 2 precursor; Kallikrein 11 precursor ; Kallikrein related peptidase 11; Kallikrein-11 inactive chain 2; KLK 11; Klk11; KLK11_HUMAN; MGC33060; Protease serine 20 trypsin like; Protease serine trypsin like; PRSS20; Serine protease 20; TLSP; Trypsin like protease; Trypsin-like protease

Target Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed.