Recombinant Human Kallikrein-14 (KLK14)

Uniprot Id

Q9P0G3

Target Species

Human

Target Name

KLK14

Target Full Name

Kallikrein-14

Target Function

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Peptidase S1 family, Kallikrein subfamily

Target Tissue Specificity

Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin

Target Synonyms

hK14; Kallikrein 14; Kallikrein like protein 6; Kallikrein-14; Kallikrein-like protein 6; KLK L6; KLK-L6; KLK14; KLK14_HUMAN

Target Background

This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants.