Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)

Uniprot Id

P05783

Target Species

Human

Target Name

KRT18

Target Full Name

Keratin, type I cytoskeletal 18

Target Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Target Involvement

Cirrhosis (CIRRH)

Target Subcellular Location

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Target Protein Families

Intermediate filament family

Target Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Target Research Area

Signal Transduction, Cell Cycle

Target Synonyms

Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46 ; Cell proliferation-inducing gene 46 protein; CK 18; CK-18; CK18; CYK 18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin-18; K 18; K18; K1C18_HUMAN; KA18; Keratin 18; Keratin 18, type I; Keratin D ; keratin, type I cytoskeletal 18; Keratin-18; Krt18

Target Background

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.