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Discover the potential of our Recombinant Human KRT18 protein in your signal transduction research, and examine its role in a variety of cellular processes, including cell proliferation, apoptosis, and cytoskeletal dynamics. KRT18, also known as Keratin 18, is a type I intermediate filament protein that forms heterodimers with type II keratins, and plays a crucial role in maintaining the structural integrity of epithelial cells. Our Recombinant Human KRT18 protein offers a full-length sequence (1-167 amino acids) for maximum functionality and bioactivity. Produced in E. coli, this protein features an N-terminal GST-tag that ensures efficient purification and detection, without compromising the protein's native structure or biological activity. Boasting a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human KRT18 protein guarantees consistent and reliable results, providing a valuable tool for your research endeavors. Choose from liquid or lyophilized powder forms to best accommodate your experimental requirements.
Discover the potential of our Recombinant Human KRT18 protein in your signal transduction research, and examine its role in a variety of cellular processes, including cell proliferation, apoptosis, and cytoskeletal dynamics. KRT18, also known as Keratin 18, is a type I intermediate filament protein that forms heterodimers with type II keratins, and plays a crucial role in maintaining the structural integrity of epithelial cells.
Our Recombinant Human KRT18 protein offers a full-length sequence (1-167 amino acids) for maximum functionality and bioactivity. Produced in E. coli, this protein features an N-terminal GST-tag that ensures efficient purification and detection, without compromising the protein’s native structure or biological activity. Boasting a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human KRT18 protein guarantees consistent and reliable results, providing a valuable tool for your research endeavors. Choose from liquid or lyophilized powder forms to best accommodate your experimental requirements.
| Cat.No | ACP02807 | Target Name | Krt18 |
|---|---|---|---|
| Target Synonyms | type I cytoskeletal 18; Keratin-18; Krt18, type I; Keratin D ; keratin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 102-396aa |
| Mol Weight | 38.0kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05783 |
|---|
Uniprot Id
P05783
Target Species
Human
Target Name
KRT18
Target Full Name
Keratin, type I cytoskeletal 18
Target Function
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Target Involvement
Cirrhosis (CIRRH)
Target Subcellular Location
Cytoplasm, perinuclear region. Nucleus, nucleolus.
Target Protein Families
Intermediate filament family
Target Tissue Specificity
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Target Research Area
Signal Transduction, Cell Cycle
Target Synonyms
Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46 ; Cell proliferation-inducing gene 46 protein; CK 18; CK-18; CK18; CYK 18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin-18; K 18; K18; K1C18_HUMAN; KA18; Keratin 18; Keratin 18, type I; Keratin D ; keratin, type I cytoskeletal 18; Keratin-18; Krt18
Target Background
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
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