Recombinant Human Kin of IRRE-like protein 1 (KIRREL), Truncated

Uniprot Id

Q96J84

Target Species

Human

Target Name

KIRREL1

Target Full Name

Kin of IRRE-like protein 1

Target Function

Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm.

Target Protein Families

Immunoglobulin superfamily

Target Tissue Specificity

Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.

Target Synonyms

FLJ10845; Kin of IRRE like (Drosophila); Kin of IRRE like; Kin of IRRE like protein 1; Kin of IRRE-like protein 1; Kin of irregular chiasm like protein 1; Kin of irregular chiasm-like protein 1; KIRR1_HUMAN; Kirrel; MGC129542; MGC129543; NEPH 1; NEPH1; Nephrin like protein 1; Nephrin related; Nephrin-like protein 1; OTTHUMP00000024055

Target Background

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).