Recombinant Human Kinesin-like protein KIF1A (KIF1A), Truncated

Uniprot Id

Q12756

Target Species

Human

Target Name

KIF1A

Target Full Name

Kinesin-like protein KIF1A

Target Function

Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites.

Target Involvement

Spastic paraplegia 30, autosomal recessive (SPG30); Neuropathy, hereditary sensory, 2C (HSN2C); Mental retardation, autosomal dominant 9 (MRD9)

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, perinuclear region. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily

Target Tissue Specificity

Expressed in neurons.

Target Synonyms

ATSV; Axonal transporter of synaptic vesicles; C2orf20; HSN2C; hUnc 104; hUnc-104; hunc104; Kif1a; KIF1A related protein; KIF1A_HUMAN; Kinesin family member 1A; Kinesin heavy chain member 1A homolog of mouse; kinesin like protein; kinesin like protein KIF1A; Kinesin-like protein KIF1A; Microtubule based motor; Microtubule based motor KIF1A; Microtubule-based motor KIF1A; MRD9; SPG30; Unc 104 and KIF1A related protein; Unc 104; Unc-104- and KIF1A-related protein; UNC104