Recombinant Human Kinesin-like protein KIF1B (KIF1B), Truncated

Uniprot Id

O60333

Target Species

Human

Target Name

KIF1B

Target Full Name

Kinesin-like protein KIF1B

Target Function

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.; Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.

Target Involvement

Charcot-Marie-Tooth disease 2A1 (CMT2A1); Neuroblastoma 1 (NBLST1); Pheochromocytoma (PCC)

Target Subcellular Location

Cytoplasm, cytoskeleton. Mitochondrion. Cell projection, axon.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily

Target Tissue Specificity

Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney,

Target Synonyms

KIF1B; KIAA0591; KIAA1448Kinesin-like protein KIF1B; Klp

Target Background

Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Predicted to be involved in chemical synaptic transmission; dense core granule cytoskeletal transport; and vesicle-mediated transport. Predicted to act upstream of or within mitochondrion transport along microtubule. Predicted to be located in cytoplasmic vesicle membrane and neuron projection. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including axon; dendrite; and microtubule. Implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Biomarker of hepatocellular carcinoma.