Recombinant Human Krueppel-like factor 2 (KLF2)

Uniprot Id

Q9Y5W3

Target Species

Human

Target Name

KLF2

Target Full Name

Krueppel-like factor 2

Target Function

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.

Target Subcellular Location

Nucleus.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Synonyms

KLF 2; Klf2; KLF2_HUMAN; Krueppel-like factor 2; Kruppel like factor 2; Kruppel like factor; Kruppel like factor LKLF; Kruppel-like factor 2 (lung); Lklf; Lung krueppel like factor; Lung krueppel-like factor; Lung Kruppel like zinc finger transcription factor

Target Background

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability.