Recombinant Human Krueppel-like factor 6 (KLF6)

Uniprot Id

Q99612

Target Species

Human

Target Name

KLF6

Target Full Name

Krueppel-like factor 6

Target Function

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development.

Target Involvement

Gastric cancer (GASC); Prostate cancer (PC)

Target Subcellular Location

Nucleus.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Tissue Specificity

Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Target Synonyms

B cell derived protein 1; B cell-derived 1; B-cell-derived protein 1; BCD1; CBA1; COPEB; Core promoter element-binding protein; CPBP; GBF; GC rich binding factor; GC rich sites binding factor GBF; GC-rich sites-binding factor GBF; Klf6; KLF6_HUMAN; Krueppel-like factor 6; Krueppel-like factor 6 isoform C; Kruppel like zinc finger protein Zf9; PAC1; Proto-oncogene BCD1; Protooncogene B cell derived 1; ST12; Suppression of tumorigenicity 12 (prostate); Suppressor of tumorigenicity 12 protein; Transcription factor Zf9; Zf9

Target Background

This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.