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Enhance your metabolic research with our premium Recombinant Human KMO protein, a critical enzyme involved in the kynurenine pathway of tryptophan degradation. Kynurenine 3-monooxygenase (KMO) catalyzes the hydroxylation of L-kynurenine to 3-hydroxykynurenine, a critical step in the production of important neuroactive metabolites such as quinolinic acid and kynurenic acid. Studying KMO and its role in tryptophan metabolism is crucial to understanding various neurological and immunological disorders. Our Recombinant Human KMO protein spans the full length of the enzyme (1-486 amino acids) and is expressed in E. coli for robust and reliable production. The N-terminal 10xHis-tag ensures efficient purification without compromising the protein's structure or function. With a purity of greater than 85% as determined by SDS-PAGE, our Recombinant Human KMO protein guarantees the quality and consistency needed for your metabolic research. Choose from liquid or lyophilized powder forms to suit your experimental requirements.
Enhance your metabolic research with our premium Recombinant Human KMO protein, a critical enzyme involved in the kynurenine pathway of tryptophan degradation. Kynurenine 3-monooxygenase (KMO) catalyzes the hydroxylation of L-kynurenine to 3-hydroxykynurenine, a critical step in the production of important neuroactive metabolites such as quinolinic acid and kynurenic acid. Studying KMO and its role in tryptophan metabolism is crucial to understanding various neurological and immunological disorders.
Our Recombinant Human KMO protein spans the full length of the enzyme (1-486 amino acids) and is expressed in E. coli for robust and reliable production. The N-terminal 10xHis-tag ensures efficient purification without compromising the protein’s structure or function. With a purity of greater than 85% as determined by SDS-PAGE, our Recombinant Human KMO protein guarantees the quality and consistency needed for your metabolic research. Choose from liquid or lyophilized powder forms to suit your experimental requirements.
| Cat.No | ACP05260 | Target Name | KMO |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-486aa | Mol Weight | 61.9 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15229 |
|---|
Uniprot Id
O15229
Target Species
Human
Target Name
KMO
Target Full Name
Kynurenine 3-monooxygenase
Target Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
Target Subcellular Location
Mitochondrion outer membrane; Multi-pass membrane protein.
Target Protein Families
Aromatic-ring hydroxylase family, KMO subfamily
Target Tissue Specificity
Highest levels in placenta and liver. Detectable in kidney.
Target Research Area
Metabolism
Target Synonyms
dJ317G22.1; kmo; KMO_HUMAN; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); Kynurenine 3 monooxygenase; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; RP1-317G22.1
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