Recombinant Human Kynurenine–oxoglutarate transaminase 3 (CCBL2)

Uniprot Id

Q6YP21

Target Species

Human

Target Name

KYAT3

Target Full Name

Kynurenine--oxoglutarate transaminase 3

Target Function

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).

Target Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family

Target Research Area

Signal Transduction

Target Synonyms

CCBL 2; Cysteine conjugate beta lyase 2; Cysteine S conjugate beta lyase 2; Cysteine-S-conjugate beta-lyase 2; DKFZp547N1117; DKFZp667D0223; KAT 3; KAT III; KAT3; KAT3_HUMAN; KATIII; kyat3; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine oxoglutarate transaminase 3; Kynurenine oxoglutarate transaminase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase 3; Kynurenine--oxoglutarate transaminase III; MGC9398; RBM1; RBMX L1; RBMXL 1; RBMXL1; RNA binding motif protein X linked like 1; RP11 82K18.3; RP4 531M19.2

Target Background

This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping.