Recombinant Human Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1)

Cat.No	ACP10488	Target Name	Lrwd1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-647	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10488

Target Name

Lrwd1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-647

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UFC0

Background Information

Uniprot Id

Q9UFC0
Target Species

Human
Target Name

LRWD1
Target Full Name

Leucine-rich repeat and WD repeat-containing protein 1
Target Function

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Target Subcellular Location

Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Target Protein Families

LRWD1 family
Target Tissue Specificity

Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).
Target Synonyms

1200011O22Rik; AU042569; AW548074; DKFZp434K1815; Leucine rich repeats and WD repeat domain containing 1; Leucine-rich repeat and WD repeat-containing protein 1; LRWD1; LRWD1_HUMAN; ORC-associated protein; ORCA; Origin recognition complex-associated protein
Target Background

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1)

Specifications

Immunogen Information

Inquire Recombinant Human Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) Now

Related Products