Recombinant Human Leucine-zipper-like transcriptional regulator 1 (LZTR1), Truncated

Uniprot Id

Q8N653

Target Species

Human

Target Name

LZTR1

Target Full Name

Leucine-zipper-like transcriptional regulator 1

Target Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.

Target Involvement

Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)

Target Subcellular Location

Endomembrane system. Recycling endosome. Golgi apparatus.

Target Synonyms

Leucine zipper like regulator 1; Leucine zipper like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; LZTR-1; Lztr1; LZTR1_HUMAN; MGC21205; TCFL2

Target Background

This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome.