Recombinant Human LIM/homeobox protein Lhx3 (LHX3)

Uniprot Id

Q9UBR4

Target Species

Human

Target Name

LHX3

Target Full Name

LIM/homeobox protein Lhx3

Target Function

Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.

Target Involvement

Pituitary hormone deficiency, combined, 3 (CPHD3)

Target Subcellular Location

Nucleus.

Target Research Area

Developmental Biology

Target Synonyms

CPHD 3; CPHD3; DKFZp762A2013; LHX 3; LHX3; LHX3_HUMAN; LIM 3; LIM homeobox 3; LIM homeobox gene 3; LIM homeobox protein 3; LIM/homeobox protein Lhx3; LIM/homeodomain protein LHX3; Lim3; M2 LHX3; mLim-3; mLIM3; P LIM

Target Background

This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms.