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Recombinant Human MAGE-like protein 2 (MAGEL2), Truncated

ACP10761

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Specifications

Cat.No	ACP10761	Target Name	MAGEL2
Target Synonyms	MAGEL2; NDNL1; MAGE-like protein 2; Necdin-like protein 1; Protein nM15	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9UJ55

Background Information

Uniprot Id

Q9UJ55
Target Species

Human
Target Name

MAGEL2
Target Full Name

MAGE-like protein 2
Target Function

Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK.
Target Involvement

Schaaf-Yang syndrome (SHFYNG)
Target Subcellular Location

Early endosome. Cytoplasm. Nucleus.
Target Tissue Specificity

Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.
Target Synonyms

MAGEL2; NDNL1; MAGE-like protein 2; Necdin-like protein 1; Protein nM15

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Recombinant Human MAGE-like protein 2 (MAGEL2), Truncated

Specifications

Immunogen Information

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