Recombinant Human MAGUK p55 subfamily member 6 (MPP6)

Uniprot Id

Q9NZW5

Target Species

Human

Target Name

PALS2

Target Full Name

Protein PALS2

Target Subcellular Location

Membrane; Peripheral membrane protein.

Target Protein Families

MAGUK family

Target Tissue Specificity

Abundant in testis, brain, and kidney with lower levels detectable in other tissues.

Target Synonyms

MAGUK p55 subfamily member 6; MAGUK p55 subfamily member 6 VELI associated MAGUK 1; MAGUK protein p55T; Membrane protein palmitoylated 6; Mpp6; MPP6_HUMAN; p55T; Palmitoylated 6 MAGUK p55 subfamily member 6; PALS2; Protein associated with Lin7 2; VAM-1; VELI associated MAGUK 1; Veli-associated MAGUK 1

Target Background

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).