Recombinant Human Mastermind-like protein 1 (MAML1), Truncated

Uniprot Id

Q92585

Target Species

Human

Target Name

MAML1

Target Full Name

Mastermind-like protein 1

Target Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Target Subcellular Location

Nucleus speckle. Note=Nuclear, in a punctate manner.

Target Protein Families

Mastermind family

Target Tissue Specificity

Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.

Target Synonyms

Mam-1; Mam1; MAML 1; Maml1; MAML1_HUMAN; Mastermind like 1; Mastermind-like protein 1

Target Background

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.