Recombinant Human Mediator of RNA polymerase II transcription subunit 12 (MED12), Truncated

Uniprot Id

Q93074

Target Species

Human

Target Name

MED12

Target Full Name

Mediator of RNA polymerase II transcription subunit 12

Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

Target Involvement

Opitz-Kaveggia syndrome (OKS); Lujan-Fryns syndrome (LUJFRYS); Ohdo syndrome, X-linked (OHDOX)

Target Subcellular Location

Nucleus.

Target Protein Families

Mediator complex subunit 12 family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Activator recruited cofactor 240 kDa component; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; CAGH45; HOPA; KIAA0192; MED12; MED12_HUMAN; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; OPA containing protein; OPA-containing protein; Thyroid hormone receptor associated protein complex 230 kDa component; Thyroid hormone receptor-associated protein complex 230 kDa component; TNRC11; Trap230; Trinucleotide repeat containing gene 11 protein; Trinucleotide repeat-containing gene 11 protein