Recombinant Human Mediator of RNA polymerase II transcription subunit 28 (MED28)

Uniprot Id

Q9H204

Target Species

Human

Target Name

MED28

Target Full Name

Mediator of RNA polymerase II transcription subunit 28

Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.

Target Subcellular Location

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.

Target Protein Families

Mediator complex subunit 28 family

Target Tissue Specificity

Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.

Target Synonyms

EG1; Endothelial-derived protein 1; FKSG20; Magicin; med28; MED28_HUMAN; Mediator complex subunit 28; Mediator of RNA polymerase II transcription subunit 28; Merlin and Grb2-interacting cytoskeletal protein; Tumor angiogenesis marker EG-1