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| Cat.No | ACP13207 | Target Name | MED8 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-268 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96G25 |
|---|
Uniprot Id
Q96G25
Target Species
Human
Target Name
MED8
Target Full Name
Mediator of RNA polymerase II transcription subunit 8
Target Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Target Subcellular Location
Nucleus.
Target Protein Families
Mediator complex subunit 8 family
Target Synonyms
Activator recruited cofactor 32 kDa component; Activator-recruited cofactor 32 kDa component; ARC32; med8; MED8_HUMAN; Mediator complex subunit 8; Mediator of RNA polymerase II transcription subunit 8; Mediator of RNA polymerase II transcription subunit 8 homolog
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