Recombinant Human Meiotic recombination protein REC8 homolog (REC8)

Uniprot Id

O95072

Target Species

Human

Target Name

REC8

Target Full Name

Meiotic recombination protein REC8 homolog

Target Function

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

Target Subcellular Location

Nucleus. Chromosome. Chromosome, centromere.

Target Protein Families

Rad21 family

Target Tissue Specificity

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level).

Target Synonyms

Cohesin Rec8p; Human homolog of rad21 S. pombe; Meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family; Meiotic recombination protein REC8 homolog; Meiotic recombination protein REC8-like 1; rec8; REC8 homolog (yeast); REC8 like 1; REC8_HUMAN; Rec8p; Recombination and sister chromatid cohesion protein homolog

Target Background

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.