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| Cat.No | ACP10958 | Target Name | MAGEF1 |
|---|---|---|---|
| Target Synonyms | MAGE F1 antigen; MAGE-F1 antigen; MAGEF 1; MAGEF1; MAGF1_HUMAN; Melanoma antigen family F; 1; Melanoma associated antigen F1; Melanoma-associated antigen F1; MGC19617 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-307 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HAY2 |
|---|
Uniprot Id
Q9HAY2
Target Species
Human
Target Name
MAGEF1
Target Full Name
Melanoma-associated antigen F1
Target Function
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
MAGE F1 antigen; MAGE-F1 antigen; MAGEF 1; MAGEF1; MAGF1_HUMAN; Melanoma antigen family F; 1; Melanoma associated antigen F1; Melanoma-associated antigen F1; MGC19617
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