Recombinant Human Metabotropic glutamate receptor 1 (GRM1), Truncated

Uniprot Id

Q13255

Target Species

Human

Target Name

GRM1

Target Full Name

Metabotropic glutamate receptor 1

Target Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina.

Target Involvement

Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13); Spinocerebellar ataxia 44 (SCA44)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 3 family

Target Tissue Specificity

Detected in brain.

Target Synonyms

Glutamate receptor metabotropic 1; glutamate receptor; metabotropic 1; GPRC1A; GRM1; GRM1-Alpha; GRM1_HUMAN; GRM1A; Metabotropic glutamate receptor 1; mGlu1; mGluR1; MGLUR1-Alpha; MGLUR1A; SCAR13

Target Background

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.