Recombinant Human Methylthioribose-1-phosphate isomerase (MRI1)

Uniprot Id

Q9BV20

Target Species

Human

Target Name

MRI1

Target Full Name

Methylthioribose-1-phosphate isomerase

Target Function

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

Target Subcellular Location

Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

Target Protein Families

EIF-2B alpha/beta/delta subunits family, MtnA subfamily

Target Synonyms

EI2BL; M1Pi; Mediator of RhoA-dependent invasion; Methylthioribose 1 phosphate isomerase 1; Methylthioribose 1 phosphate isomerase homolog; Methylthioribose-1-phosphate isomerase; MGC3207; MRDI; mri1; MTNA; MTNA_HUMAN; MTR-1-P isomerase; S methyl 5 thioribose 1 phosphate isomerase 1; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF 2B; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein; Ypr118w

Target Background

This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD).