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The expression region of this recombinant Human MAP1LC3B covers amino acids 1-120. This MAP1LC3B protein is theoretically predicted to have a molecular weight of 15.2 kDa. The MAP1LC3B protein was expressed in yeast. The MAP1LC3B coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant MAP1LC3B protein in following stages of expression and purification.The human microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B) is a crucial protein involved in autophagy, a cellular process responsible for degrading and recycling damaged or dysfunctional cellular components. MAP1LC3B is a key component of the autophagosome, a double-membrane vesicle that engulfs cellular material targeted for degradation. It undergoes a series of post-translational modifications during autophagy, including lipidation, which facilitates its association with autophagosomal membranes. MAP1LC3B is widely used as a marker for autophagy, and its levels and localization are indicative of autophagic activity. Understanding the function of MAP1LC3B contributes to unraveling the complex regulatory mechanisms of autophagy and its implications in various physiological and pathological conditions, including cancer and neurodegenerative diseases.
The expression region of this recombinant Human MAP1LC3B covers amino acids 1-120. This MAP1LC3B protein is theoretically predicted to have a molecular weight of 15.2 kDa. The MAP1LC3B protein was expressed in yeast. The MAP1LC3B coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant MAP1LC3B protein in following stages of expression and purification.The human microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B) is a crucial protein involved in autophagy, a cellular process responsible for degrading and recycling damaged or dysfunctional cellular components. MAP1LC3B is a key component of the autophagosome, a double-membrane vesicle that engulfs cellular material targeted for degradation. It undergoes a series of post-translational modifications during autophagy, including lipidation, which facilitates its association with autophagosomal membranes. MAP1LC3B is widely used as a marker for autophagy, and its levels and localization are indicative of autophagic activity. Understanding the function of MAP1LC3B contributes to unraveling the complex regulatory mechanisms of autophagy and its implications in various physiological and pathological conditions, including cancer and neurodegenerative diseases.
| Cat.No | ACP01254 | Target Name | MAP1LC3B |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 1-120aa | Mol Weight | 15.2 kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9GZQ8 |
|---|
Uniprot Id
Q9GZQ8
Target Species
Human
Target Name
MAP1LC3B
Target Full Name
Microtubule-associated protein 1 light chain 3 beta
Target Function
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
Target Subcellular Location
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor.
Target Protein Families
ATG8 family
Target Tissue Specificity
Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.
Target Research Area
Cancer
Target Synonyms
ATG8F; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; LC3B; LC3II; MAP1 light chain 3 like protein 2; MAP1 light chain 3-like protein 2; MAP1A/1BLC3; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1ALC3; MAP1LC3B a; Map1lc3b; Microtubule associated protein 1 light chain 3 beta; Microtubule-associated protein 1 light chain 3 beta; Microtubule-associated proteins 1A/1B light chain 3B; MLP3B_HUMAN
Target Background
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
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