Recombinant Human Mitochondrial 2-oxodicarboxylate carrier (SLC25A21), Truncated

Uniprot Id

Q9BQT8

Target Species

Human

Target Name

SLC25A21

Target Full Name

Mitochondrial 2-oxodicarboxylate carrier

Target Function

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

Target Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Target Protein Families

Mitochondrial carrier (TC 2.A.29) family

Target Tissue Specificity

Expressed in placenta, gall bladder and colon.

Target Synonyms

SLC25A21; ODC; Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21

Target Background

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.