Recombinant Human Mitofusin-1 (MFN1), Truncated

Uniprot Id

Q8IWA4

Target Species

Human

Target Name

MFN1

Target Full Name

Mitofusin-1

Target Function

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.

Target Subcellular Location

Mitochondrion outer membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.

Target Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily

Target Tissue Specificity

Detected in kidney and heart (at protein level). Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.

Target Synonyms

MFN1; Mitofusin-1; Fzo homolog; Transmembrane GTPase MFN1

Target Background

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.