Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5), Truncated

Uniprot Id

Q9Y4K4

Target Species

Human

Target Name

MAP4K5

Target Full Name

Mitogen-activated protein kinase kinase kinase kinase 5

Target Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Target Tissue Specificity

Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.

Target Synonyms

MAP4K5; Mitogen-activated protein kinase kinase kinase kinase 5; EC 2.7.11.1; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5

Target Background

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.