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Discover the exceptional quality of our Recombinant Human CD14 protein, designed to support your immunology research requirements. Expressed in E. coli, this full length mature protein (20-345aa) is equipped with an N-terminal GST-tag for seamless purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our CD14 protein guarantees reliable and consistent outcomes. Explore the intricacies of monocyte differentiation antigens and their roles in immune responses using our premium recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human CD14 protein is a valuable addition to your immunology research arsenal.
Discover the exceptional quality of our Recombinant Human CD14 protein, designed to support your immunology research requirements. Expressed in E. coli, this full length mature protein (20-345aa) is equipped with an N-terminal GST-tag for seamless purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our CD14 protein guarantees reliable and consistent outcomes.
Explore the intricacies of monocyte differentiation antigens and their roles in immune responses using our premium recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human CD14 protein is a valuable addition to your immunology research arsenal.
| Cat.No | ACP02786 | Target Name | CD14 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 20-345aa | Mol Weight | 62.2kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08571 |
|---|
Uniprot Id
P08571
Target Species
Human
Target Name
CD14
Target Full Name
Monocyte differentiation antigen CD14
Target Function
Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus.
Target Tissue Specificity
Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Target Research Area
Immunology
Target Synonyms
CD 14; CD_antigen=CD14; CD14; CD14 antigen; CD14 molecule; CD14_HUMAN; LPS-R; Mo2; Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14 urinary form; Monocyte differentiation antigen CD14; membrane-bound form; Myeloid cell specific leucine rich glycoprotein; Myeloid cell-specific leucine-rich glycoprotein
Target Background
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein.
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