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This Recombinant Human SMAD3 protein is specifically designed to support your transcription research. This full-length protein (1-425aa) is expressed in a Baculovirus expression system and is equipped with an N-terminal 10xHis-tag, facilitating effortless purification and detection. Our SMAD3 protein has a purity of greater than 85% as determined by SDS-PAGE, ensuring consistent performance and reliable results. Dive into the complex functions of Mothers against decapentaplegic homolog 3 with our premium recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human SMAD3 protein offers the versatility and quality you need to advance your research endeavors and uncover new insights.
This Recombinant Human SMAD3 protein is specifically designed to support your transcription research. This full-length protein (1-425aa) is expressed in a Baculovirus expression system and is equipped with an N-terminal 10xHis-tag, facilitating effortless purification and detection. Our SMAD3 protein has a purity of greater than 85% as determined by SDS-PAGE, ensuring consistent performance and reliable results.
Dive into the complex functions of Mothers against decapentaplegic homolog 3 with our premium recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human SMAD3 protein offers the versatility and quality you need to advance your research endeavors and uncover new insights.
| Cat.No | ACP03674 | Target Name | SMAD3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 1-425aa | Mol Weight | 50.6 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P84022 |
|---|
Uniprot Id
P84022
Target Species
Human
Target Name
SMAD3
Target Full Name
Mothers against decapentaplegic homolog 3
Target Function
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Target Involvement
Colorectal cancer (CRC); Loeys-Dietz syndrome 3 (LDS3)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Dwarfin/SMAD family
Target Research Area
Transcription
Target Synonyms
DKFZP586N0721; DKFZp686J10186; hMAD 3; hMAD-3; hSMAD3; HSPC193; HST17436 ; JV15 2; JV15-2; JV152; LDS1C; LDS3; MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD homolog 3; Mad homolog JV15 2; Mad protein homolog; MAD; mothers against decapentaplegic homolog 3; Mad3; MADH 3; MADH3; MGC60396; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; SMA and MAD related protein 3; SMAD 3; SMAD; SMAD family member 3; SMAD; mothers against DPP homolog 3; Smad3; SMAD3_HUMAN
Target Background
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3.
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