Recombinant Human Myozenin-2 (MYOZ2)

Uniprot Id

Q9NPC6

Target Species

Human

Target Name

MYOZ2

Target Full Name

Myozenin-2

Target Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Target Involvement

Cardiomyopathy, familial hypertrophic 16 (CMH16)

Target Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line.

Target Protein Families

Myozenin family

Target Tissue Specificity

Expressed specifically in heart and skeletal muscle.

Target Synonyms

C4orf5; Calcineurin binding protein calsarcin 1; Calsarcin 1; Calsarcin-1; Calsarcin1; CMH16; CS 1; CS1; FATZ related protein 2; FATZ-related protein 2; Muscle specific protein; MYOZ 2; MYOZ2; MYOZ2_HUMAN; Myozenin-2; Myozenin2

Target Background

The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder.