Recombinant Human Myristoylated alanine-rich C-kinase substrate (MARCKS)

Uniprot Id

P29966

Target Species

Human

Target Name

MARCKS

Target Full Name

Myristoylated alanine-rich C-kinase substrate

Target Function

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Target Subcellular Location

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.

Target Protein Families

MARCKS family

Target Synonyms

80 kDa protein; 80K L; 80K L protein; 80K-L protein; 80KL; 81 kDa protein; light chain; light chain; MACS; MARCKS; MARCS; MARCS_HUMAN; MGC52672; myristoylated alanine rich C kinase substrate; Myristoylated alanine rich protein kinase C substrate (MARCKS; 80K L); Myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; Phosphomyristin; PKCSL; PRKCSL; protein kinase C substrate 80 kDa protein light chain; Protein kinase C substrate

Target Background

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.