Recombinant Human N (G),N (G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2)

Uniprot Id

O95865

Target Species

Human

Target Name

DDAH2

Target Full Name

Putative hydrolase DDAH2

Target Function

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Target Subcellular Location

Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.

Target Protein Families

DDAH family

Target Tissue Specificity

Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.

Target Research Area

Neuroscience

Target Synonyms

DDAH; DDAH II; DDAH-2; DDAH2; DDAH2_HUMAN; DDAHII; Dimethylargininase 2; Dimethylargininase-2; Dimethylarginine dimethylaminohydrolase 2; Dimethylarginine dimethylaminohydrolase II; G6a; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; NG dimethylarginine dimethylamino hydrolase homolog; NG30; OTTHUMP00000029307; OTTHUMP00000029310; OTTHUMP00000174488; OTTHUMP00000174489; Protein G6a; S phase protein; S-phase protein

Target Background

This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants.