Recombinant Human NACHT, LRR and PYD domains-containing protein 4 (NLRP4), Truncated

Uniprot Id

Q96MN2

Target Species

Human

Target Name

NLRP4

Target Full Name

NACHT, LRR and PYD domains-containing protein 4

Target Function

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Target Protein Families

NLRP family

Target Synonyms

Cancer/testis antigen 58; CLR19.5; CT58; FLJ32126; NACHT, leucine rich repeat and PYD containing 4; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NALP4_HUMAN; NLR family, pyrin domain containing 4; NLRP4; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT containing protein 2; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN containing APAF1 like protein 4; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; RNH2