Recombinant Human NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)

Uniprot Id

O95178

Target Species

Human

Target Name

NDUFB2

Target Full Name

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Target Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Target Protein Families

Complex I NDUFB2 subunit family

Target Synonyms

CI-AGGG; Complex I-AGGG; mitochondrial; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2; NADH-ubiquinone oxidoreductase AGGG subunit; NDUB2_HUMAN; NDUFB2

Target Background

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.