Recombinant Human NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1)

Cat.No	ACP23194	Target Name	NDUFV1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	21-464	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23194

Target Name

NDUFV1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

21-464

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P49821

Background Information

Uniprot Id

P49821
Target Species

Human
Target Name

NDUFV1
Target Full Name

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Target Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Target Involvement

Leigh syndrome (LS); Mitochondrial complex I deficiency (MT-C1D)
Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families

Complex I 51 kDa subunit family
Target Synonyms

CI 51kD; CI-51kD; CI51KD; Complex I 51kD; Complex I-51kD; FLJ59059; mitochondrial; NADH dehydrogenase (ubiquinone) flavoprotein 1; NADH dehydrogenase [ubiquinone] flavoprotein 1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NADH dehydrogenase flavoprotein 1; NADH ubiquinone oxidoreductase 51 kDa subunit; NADH ubiquinone oxidoreductase; NADH ubiquinone oxidoreductase core subunit V1; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV 1; ndufv1; NDUV1_HUMAN; UQOR1
Target Background

The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10, 000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Recombinant Human NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1)

Specifications

Immunogen Information

Inquire Recombinant Human NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) Now

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