Recombinant Human NADH-ubiquinone oxidoreductase chain 5 (MT-ND5), Truncated

Uniprot Id

P03915

Target Species

Human

Target Name

MT-ND5

Target Full Name

NADH-ubiquinone oxidoreductase chain 5

Target Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Target Involvement

Leber hereditary optic neuropathy (LHON); Leigh syndrome (LS); Mitochondrial complex I deficiency (MT-C1D); Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)

Target Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Target Protein Families

Complex I subunit 5 family

Target Synonyms

Complex I, subunit ND5; EC 1.6.5.3; Mitochondrially encoded NADH dehydrogenase 5; MT ND5; MT-ND5; MTND 5; MTND5; NAD5; NADH dehydrogenase subunit 5 (complex I); NADH dehydrogenase subunit 5; NADH ubiquinone oxidoreductase , subunit ND5; NADH ubiquinone oxidoreductase chain 5; NADH-ubiquinone oxidoreductase chain 5; NADH5; ND5; NU5M_HUMAN

Target Background

Contributes to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in central nervous system; heart; liver; metanephros; and retina. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5).