Recombinant Human natriuretic peptide B (NPPB), Truncated

Discover the benefits of our premium Recombinant Human NPPB protein, an essential tool for researchers studying signal transduction. Natriuretic peptides B is expressed in E. coli and features a partial protein sequence (37-71aa) to provide robust results across a range of research applications. Equipped with an N-terminal GST-tag, this Recombinant Human NPPB protein offers straightforward purification and detection for streamlined experimental workflows. With a purity greater than 90% as determined by SDS-PAGE, you can trust in the quality of this protein for all your signal transduction research needs. Available in both liquid and lyophilized powder forms, our Recombinant Human NPPB protein provides flexibility and adaptability for your specific research requirements.

ACP02265

Discover the benefits of our premium Recombinant Human NPPB protein, an essential tool for researchers studying signal transduction. Natriuretic peptides B is expressed in E. coli and features a partial protein sequence (37-71aa) to provide robust results across a range of research applications.
Equipped with an N-terminal GST-tag, this Recombinant Human NPPB protein offers straightforward purification and detection for streamlined experimental workflows. With a purity greater than 90% as determined by SDS-PAGE, you can trust in the quality of this protein for all your signal transduction research needs. Available in both liquid and lyophilized powder forms, our Recombinant Human NPPB protein provides flexibility and adaptability for your specific research requirements.

Number

Cat.No	ACP02265	Target Name	NPPB
Target Synonyms	ANFB_HUMAN; BNP; BNP(1-32); BNP(5-29); BNP-32; Brain type natriuretic peptide; Gamma brain natriuretic peptide; Gamma-brain natriuretic peptide; Natriuretic peptide precursor B; nppb; NT proBNP	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	37-71aa
Mol Weight	31.0kDa	Protein Length	Partial
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02265

Target Name

NPPB

Target Synonyms

ANFB_HUMAN; BNP; BNP(1-32); BNP(5-29); BNP-32; Brain type natriuretic peptide; Gamma brain natriuretic peptide; Gamma-brain natriuretic peptide; Natriuretic peptide precursor B; nppb; NT proBNP

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

37-71aa

Mol Weight

31.0kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P16860

Background Information

Uniprot Id

P16860
Target Species

Human
Target Name

NPPB
Target Full Name

Natriuretic peptides B
Target Function

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.; May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32.; May have a role in cardio-renal homeostasis. Able to promote the production of cGMP.
Target Subcellular Location

[NT-proBNP]: Secreted.; [proBNP(3-108)]: Secreted.; [Brain natriuretic peptide 32]: Secreted.; [BNP(3-32)]: Secreted.
Target Protein Families

Natriuretic peptide family
Target Tissue Specificity

[Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level). Detected in the kidney distal tubular cells (at protein level).
Target Research Area

Signal Transduction
Target Synonyms

ANFB_HUMAN; BNP; BNP(1-32); BNP(5-29); BNP-32; Brain type natriuretic peptide; Gamma brain natriuretic peptide; Gamma-brain natriuretic peptide; Natriuretic peptide precursor B; nppb; NT proBNP
Target Background

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.

Recombinant Human natriuretic peptide B (NPPB), Truncated

Specifications

Immunogen Information

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