Recombinant Human Neuronal pentraxin-2 (NPTX2)

Uniprot Id

P47972

Target Species

Human

Target Name

NPTX2

Target Full Name

Neuronal pentraxin-2

Target Function

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.

Target Synonyms

apexin; NARP; neuronal activity-regulated pentaxin; Neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP 2; NP-II; NP2; NPII ; NPTX2; NPTX2_HUMAN; pentraxin II, neuronal

Target Background

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.