Recombinant Human Neurotrypsin (PRSS12), Truncated

Uniprot Id

P56730

Target Species

Human

Target Name

PRSS12

Target Full Name

Neurotrypsin

Target Function

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

Target Involvement

Mental retardation, autosomal recessive 1 (MRT1)

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Brain and Leydig cells of the testis.

Target Research Area

Cell Biology

Target Synonyms

BSSP 3; BSSP3; Leydin; MGC12722; Motopsin; MRT1; NETR_HUMAN; Neurotrypsin; protease; serine; 12 (neurotrypsin; motopsin); Prss12; Serine protease 12

Target Background

This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1).