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The expression region of this recombinant Human DEFA1 covers amino acids 1-94. This DEFA1 protein is theoretically predicted to have a molecular weight of 37.2 kDa. Expression of this DEFA1 protein is conducted in e.coli. The DEFA1 gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant DEFA1 protein during the following stages.Neutrophil defensin 1 (DEFA1) is a member of the defensin family, small cationic peptides with antimicrobial properties. DEFA1 is primarily produced by neutrophils, a type of white blood cell, and serves as part of the innate immune system's defense against microbial infections. This antimicrobial peptide exerts its function by disrupting the microbial cell membrane, leading to cell death. Beyond its antimicrobial role, DEFA1 has been implicated in various immune responses and inflammatory processes. Research areas related to DEFA1 include investigations into its role in host-pathogen interactions, immune regulation, and potential therapeutic applications in combating infectious diseases. Understanding the functions of DEFA1 contributes to insights into the immune system's defense mechanisms.
The expression region of this recombinant Human DEFA1 covers amino acids 1-94. This DEFA1 protein is theoretically predicted to have a molecular weight of 37.2 kDa. Expression of this DEFA1 protein is conducted in e.coli. The DEFA1 gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant DEFA1 protein during the following stages.Neutrophil defensin 1 (DEFA1) is a member of the defensin family, small cationic peptides with antimicrobial properties. DEFA1 is primarily produced by neutrophils, a type of white blood cell, and serves as part of the innate immune system’s defense against microbial infections. This antimicrobial peptide exerts its function by disrupting the microbial cell membrane, leading to cell death. Beyond its antimicrobial role, DEFA1 has been implicated in various immune responses and inflammatory processes. Research areas related to DEFA1 include investigations into its role in host-pathogen interactions, immune regulation, and potential therapeutic applications in combating infectious diseases. Understanding the functions of DEFA1 contributes to insights into the immune system’s defense mechanisms.
| Cat.No | ACP02304 | Target Name | DEFA1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-94aa | Mol Weight | 37.2kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P59665 |
|---|
Uniprot Id
P59665
Target Species
Human
Target Name
DEFA1
Target Full Name
Neutrophil defensin 1
Target Function
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
Target Subcellular Location
Secreted.
Target Protein Families
Alpha-defensin family
Target Synonyms
alpha 1; DEF1; DEF1_HUMAN; DEFA1; DEFA1B; DEFA2; Defensin 1; Defensin; Defensin; alpha 1; Defensin; alpha 1; myeloid related sequence; Defensin; alpha 2; HNP-1; HNP-2; HNP1; HP-1; HP-2; HP1; HP2; MRS; Myeloid related sequence; Neutrophil defensin 1; Neutrophil defensin 2
Target Background
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
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