Recombinant Human Non-receptor tyrosine-protein kinase TNK1 (TNK1)

Uniprot Id

Q13470

Target Species

Human

Target Name

TNK1

Target Full Name

Non-receptor tyrosine-protein kinase TNK1

Target Function

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Target Protein Families

Protein kinase superfamily, Tyr protein kinase family

Target Tissue Specificity

Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small in

Target Synonyms

TNK1; Non-receptor tyrosine-protein kinase TNK1; EC 2.7.10.2; CD38 negative kinase 1

Target Background

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.