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| Cat.No | ACP14490 | Target Name | NSMCE1 |
|---|---|---|---|
| Target Synonyms | NSMCE1; HSPC333; HSPC337; Non-structural maintenance of chromosomes element 1 homolog; Non-SMC element 1 homolog; EC 2.3.2.27 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-266 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WV22 |
|---|
Uniprot Id
Q8WV22
Target Species
Human
Target Name
NSMCE1
Target Full Name
Non-structural maintenance of chromosomes element 1 homolog
Target Function
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors
Target Subcellular Location
Nucleus. Chromosome, telomere.
Target Protein Families
NSE1 family
Target Synonyms
NSMCE1; HSPC333; HSPC337; Non-structural maintenance of chromosomes element 1 homolog; Non-SMC element 1 homolog; EC 2.3.2.27
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