Recombinant Human Nonsense-mediated mRNA decay factor SMG7 (SMG7), Truncated

Uniprot Id

Q92540

Target Species

Human

Target Name

SMG7

Target Full Name

Nonsense-mediated mRNA decay factor SMG7

Target Function

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.

Target Synonyms

breast cancer-associated antigen SGA-56M; C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1-like protein C; EST1C; ever shorter telomeres 1C; FLJ23717; hSMG-7; nonsense mediated mRNA decay factor (C. elegans); Protein SMG7; SGA56M; SMG 7; SMG-7 homolog; Smg7; SMG7_HUMAN

Target Background

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.