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Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB)

ACP01975

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Specifications

Cat.No	ACP01975	Target Name	NOTCH2NLB
Target Synonyms	NOTCH2NLB; Notch homolog 2 N-terminal-like protein B	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	26-275aa
Mol Weight	34.9 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P0DPK3

Background Information

Uniprot Id

P0DPK3
Target Species

Human
Target Name

NOTCH2NLB
Target Full Name

Notch homolog 2 N-terminal-like protein B
Target Function

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation
Target Subcellular Location

Secreted.
Target Tissue Specificity

Expressed in radial glia neural stem cells during cortical development.
Target Research Area

others
Target Synonyms

NOTCH2NLB; Notch homolog 2 N-terminal-like protein B

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Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB)

Specifications

Immunogen Information

Inquire Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB) Now

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