Recombinant Human Nuclear pore glycoprotein p62 (NUP62)

Uniprot Id

P37198

Target Species

Human

Target Name

NUP62

Target Full Name

Nuclear pore glycoprotein p62

Target Function

Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.

Target Involvement

Infantile striatonigral degeneration (SNDI)

Target Subcellular Location

Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Nucleoporin NSP1/NUP62 family

Target Synonyms

NUP62; Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62

Target Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.