Recombinant Human Oncostatin-M-specific receptor subunit beta (OSMR), Truncated

Uniprot Id

Q99650

Target Species

Human

Target Name

OSMR

Target Full Name

Oncostatin-M-specific receptor subunit beta

Target Function

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

Target Involvement

Amyloidosis, primary localized cutaneous, 1 (PLCA1)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Type I cytokine receptor family, Type 2 subfamily

Target Tissue Specificity

Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells.

Target Synonyms

IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M receptor; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; Oncostatin-M-specific receptor subunit beta; Osmr; OSMR_HUMAN; OSMRB

Target Background

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.