Recombinant Human Oocyte-expressed protein homolog (OOEP)

Uniprot Id

A6NGQ2

Target Species

Human

Target Name

OOEP

Target Full Name

Oocyte-expressed protein homolog

Target Function

As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis. As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

KHDC1 family

Target Synonyms

C6orf156; FLOPED; HOEP19; KH homology domain-containing protein 2; KHDC2; Oocyte expressed protein; Oocyte- and embryo-specific protein 19; Oocyte-expressed protein homolog; OOEP; OOEP_HUMAN