Recombinant Human Opioid-binding protein/cell adhesion molecule (OPCML)

Uniprot Id

Q14982

Target Species

Human

Target Name

OPCML

Target Full Name

Opioid-binding protein/cell adhesion molecule

Target Function

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Target Involvement

Ovarian cancer (OC)

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Target Protein Families

Immunoglobulin superfamily, IgLON family

Target Synonyms

GM181; IgLON family member 1; IGLON1; OBCAM; OPCM; OPCM_HUMAN; OPCML; Opiate binding cell adhesion molecule; Opioid binding cell adhesion molecule; Opioid binding protein/cell adhesion molecule; Opioid binding protein/cell adhesion molecule-like; Opioid binding protein/cell adhesion molecule-like preprotein; Opioid-binding cell adhesion molecule; Opioid-binding protein/cell adhesion molecule

Target Background

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.