Recombinant Human Opticin (OPTC)

Uniprot Id

Q9UBM4

Target Species

Human

Target Name

OPTC

Target Full Name

Opticin

Target Function

Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily

Target Tissue Specificity

Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subch

Target Synonyms

Oculoglycan; OPT; OPT_HUMAN; OPTC; Opticin

Target Background

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).